A Cross-Sectional Study on the Prevalence and Risk Factors of Rabies in Kandahar Province
DOI:
https://doi.org/10.62810/jnsr.v4i1.307Keywords:
Kandahar province, Prevalence, Rabies, Risk factors, Zoonotic diseaseAbstract
Rabies is an acute and fatal viral zoonotic disease transmitted to humans primarily through the bites of infected animals. Globally, approximately 60,000 human deaths occur annually, and the mortality rate in humans approaches 100% once clinical symptoms appear. In Afghanistan, rabies-related morbidity and mortality remain significant. A cross-sectional study was conducted from 2020 to 2024 to assess rabies prevalence in Kandahar City and surrounding areas. During this period, 524 human dog-bite cases suspected of rabies exposure were recorded in Kandahar Province, with 16.7% from urban areas and 83.3% from rural communities. Males accounted for over 71% of cases, and 75.1% were individuals aged 5 or older, while 24.2% were children under 5. All exposures were from dog bites; no cases involved other animals. Key risk factors identified included limited knowledge (20% unaware of rabies), difficulty accessing vaccination services, presence of unvaccinated dogs and cats, and limited healthcare availability in rural areas. Rural communities and young children were at the highest risk. These findings underscore the urgent need for enhanced public education, expanded animal vaccination programs, and improved healthcare access, particularly in underserved regions. Targeted interventions to address knowledge gaps, promote preventive practices, and improve healthcare availability are critical to reducing rabies incidence in Kandahar Province.
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References
Abela-Ridder, B. (2015). Rabies: 100 percent fatal, 100 percent preventable. Veterinary Record, 177(6), 148–149. https://doi.org/10.1136/vr.h4051 DOI: https://doi.org/10.1136/vr.h4196
Acharya, K. P., Subedi, D., & Wilson, R. T. (2021). Rabies control in South Asia requires a One Health approach. One Health, 12, 100215. https://doi.org/10.1016/j.onehlt.2020.100215 DOI: https://doi.org/10.1016/j.onehlt.2021.100215
Adedeji, A. O., Okonko, I. O., Eyarefe, O. D., Adedeji, O. B., Babalola, E. T., Ojezele, M. O., ... & Amusan, T. A. (2010). An overview of rabies: History, epidemiology, control, and possible elimination. African Journal of Microbiology Research, 4(22), 2327–2338. Link
Awoyomi, O. J., & Ogundipe, G. A. (2019). Dog bites among teenagers in Ogun State, Nigeria. Alexandria Journal for Veterinary Sciences, 62(1). https://doi.org/10.5455/ajvs.29307 DOI: https://doi.org/10.5455/ajvs.50355
Bilal, A. (2021). Rabies is a zoonotic disease: A literature review. Occupational Medicine & Health Affairs, 9(2). Link
Chen, S. J., Rai, C. I., Wang, S. C., & Chen, Y. C. (2025). Infection and prevention of rabies viruses. Microorganisms, 13(2), 380. https://doi.org/10.3390/microorganisms13020380 DOI: https://doi.org/10.3390/microorganisms13020380
Cochran, W. G. (1977). Sampling techniques. John Wiley & Sons. Link
Dahourou, L. D., Savadogo, M., Tapsoba, R. A. S., Kaboré, B. A., Konaté, A., Zerbo, M., ... & Traoré, A. (2021). Dog ownership, demographics, owners’ knowledge of rabies, and factors associated with canine rabies vaccination in urban and rural areas of Dedougou, Burkina Faso. Veterinary and Animal Science, 14, 100205. https://doi.org/10.1016/j.vas.2021.100205 DOI: https://doi.org/10.1016/j.vas.2021.100205
Dodet, B., Goswami, A., Gunasekera, A., de Guzman, F., Jamali, S., Montalban, C., ... & Ziauddin, A. (2008). Rabies awareness in eight Asian countries. Vaccine, 26(50), 6344–6348. https://doi.org/10.1016/j.vaccine.2008.09.040 DOI: https://doi.org/10.1016/j.vaccine.2008.09.003
Gautam, H., Kutlehria, A., Katoch, K., & Verma, K. K. (2024). Rhabdoviruses: Complex neuropathogenic mechanism, molecular virology, epidemiology, and treatment. Asian Journal of Pharmacy and Technology, 14(1), 59–64. https://doi.org/10.52711/2231-5713.2024.00011 DOI: https://doi.org/10.52711/2231-5713.2024.00012
Gill, G. S., Singh, B. B., Dhand, N. K., Aulakh, R. S., Sandhu, B. S., Ward, M. P., & Brookes, V. J. (2019). Estimation of the prevalence of animal rabies in Punjab, India. PLoS ONE, 14(9), e0222198. https://doi.org/10.1371/journal.pone.0222198 DOI: https://doi.org/10.1371/journal.pone.0222198
Gongal, G., & Wright, A. E. (2011). Human rabies in the WHO Southeast Asia Region: Forward steps for elimination. Advances in Preventive Medicine, 2011, 383870. https://doi.org/10.4061/2011/383870 DOI: https://doi.org/10.4061/2011/383870
Hareza, D. A., Langley, R., Ma, X., Wallace, R., & Rupprecht, C. E. (2023). Rabies in rodents and lagomorphs in the USA, 2011–2020. Journal of Wildlife Diseases, 59(4), 734–742. https://doi.org/10.7589/JWD-D-22-00110 DOI: https://doi.org/10.7589/JWD-D-23-00036
Jemberu, W. T., Molla, W., Almaw, G., & Alemu, S. (2013). Prevalence of rabies in humans and domestic animals and people's awareness in the North Gondar Zone, Ethiopia. PLoS Neglected Tropical Diseases, 7(5), e2216. https://doi.org/10.1371/journal.pntd.0002216 DOI: https://doi.org/10.1371/journal.pntd.0002216
Karshima, N. S., Kujul, N. B., Ogbu, K. I., Abdullateef, M. H., Dung, P. A., Salihu, A. A., ... & Paman, N. D. (2013). Prevalence and risk factors associated with rabies and dog bites among dogs involved in bites in Plateau State, Nigeria, 2011–2012. Journal on Animal Science Advances, 3(3), 114–120. Link DOI: https://doi.org/10.5455/jasa.20130331050415
Knobel, D. L., Cleaveland, S., Coleman, P. G., Fèvre, E. M., Meltzer, M. I., Miranda, M. E. G., ... & Meslin, F. X. (2005). Re-evaluating the burden of rabies in Africa and Asia. Bulletin of the World Health Organization, 83(5), 360–368. Link
Madjadinan, A., Hattendorf, J., Mindekem, R., Mbaipago, N., Moyengar, R., Gerber, F., ... & Lechenne, M. (2020). Identification of risk factors for rabies exposure and access to post-exposure prophylaxis in Chad. Acta Tropica, 209, 105484. https://doi.org/10.1016/j.actatropica.2020.105484 DOI: https://doi.org/10.1016/j.actatropica.2020.105484
Mamoudou, S., Parfait, O., Ismaël, D., Apoline, S. K., & Fla, K. (2020). Knowledge of health personnel on human anti-rabies treatment before and after exposure in the city of Ouagadougou, Burkina Faso. Journal of Neuroinfectious Diseases, 11(303), 1–5. Link
Mughal, F. B., & Ali, B. H. I. (2018). Epidemiology of rabies in Pakistan: A review of literature. Journal of Infectious Disease and Medical Microbiology, 2(1), 18–21. Link
Naeemi, S., Saeed, K. M. I., Hakim, M. S., & Ibrahimi, M. G. (2025). Nosocomial outbreak of Crimean-Congo hemorrhagic fever (CCHF) among health workers in Kandahar Province, Afghanistan, 2023: A case-control study. Afghanistan Journal of Infectious Diseases, 3(1), 91–100. Link DOI: https://doi.org/10.60141/ajid.78
Oertli, E. H. (2019). Rabies postexposure prophylaxis: Who, what, when, where, why, and how. In Rabies: Clinical Considerations and Exposure Evaluations (p. 79). Link DOI: https://doi.org/10.1016/B978-0-323-63979-8.00006-4
Rocha, S. M., De Oliveira, S. V., Heinemann, M. B., & Gonçalves, V. S. P. (2017). Epidemiological profile of wild rabies in Brazil (2002–2012). Transboundary and Emerging Diseases, 64(2), 624–633. https://doi.org/10.1111/tbed.12395 DOI: https://doi.org/10.1111/tbed.12428
Rupprecht, C. E., & Dietzschold, B. (2017). Rabies symptoms, diagnosis, prophylaxis, and treatment. Tropical Medicine and Infectious Disease, 2(4), 59. https://doi.org/10.3390/tropicalmed2040059 DOI: https://doi.org/10.3390/tropicalmed2040059
Sangary, M., Ahmadi, Z., & Ramaki, E. (2023). A cross-sectional study of knowledge, attitude, and practice regarding rabies among residents of Kabul City, Afghanistan. Veterinary Medicine & Public Health Journal, 4(3). https://doi.org/10.33899/vmphj.2023.180642 DOI: https://doi.org/10.31559/VMPH2023.4.3.3
Suhrabi, A. (2023, May 31). Ministry of Health: Last year, more than 33,000 cases of dog bites were registered in the country. Pajhwok Afghan News. Link
Takayama, N. (2008). Rabies: A preventable but incurable disease. Journal of Infection and Chemotherapy, 14(1), 8–14. https://doi.org/10.1007/s10156-007-0578-7 DOI: https://doi.org/10.1007/s10156-007-0573-0
Tenzin, & Ward, M. P. (2012). Review of rabies epidemiology and control in South, Southeast, and East Asia: Past, present, and prospects for elimination. Zoonoses and Public Health, 59(7), 451–467. https://doi.org/10.1111/j.1863-2378.2012.01489.x DOI: https://doi.org/10.1111/j.1863-2378.2012.01489.x
Verdoes, L., Luppino, F. S., Wallinga, P. J., & Visser, P. L. G. (2021). Delayed rabies post-exposure prophylaxis treatment among Dutch travelers during their stay abroad: A comprehensive analysis. Journal of Travel Medicine, 28(3), taaa240. https://doi.org/10.1093/jtm/taaa240 DOI: https://doi.org/10.1093/jtm/taaa240
World Health Organization. (2018). WHO expert consultation on rabies: Third report (Vol. 1012). World Health Organization. Link
World Health Organization. (2022). Guide to introducing the human rabies vaccine into national immunization programs. World Health Organization. Link
World Health Organization. (2023). WHO expert consultation on rabies: Third report (Vol. 1012). World Health Organization. Link
Yibrah, M., & Damtie, D. (2015). Prevalence of human rabies exposure and associated factors at the Gondar Health Center, Ethiopia: A three-year retrospective study. Infectious Diseases of Poverty, 4, 1–6. https://doi.org/10.1186/s40249-015-0065-1 DOI: https://doi.org/10.1186/2049-9957-4-3
Yousaf, M. Z., Qasim, M., Zia, S., Rehman Khan, M. U., Ashfaq, U. A., & Khan, S. (2012). Rabies: Molecular virology, diagnosis, prevention, and treatment. Virology Journal, 9, 50. https://doi.org/10.1186/1743-422X-9-50 DOI: https://doi.org/10.1186/1743-422X-9-50
Zhou, H., Vong, S., Liu, K., Li, Y., Mu, D., Wang, L., ... & Yu, H. (2016). Human rabies in China, 1960–2014: A descriptive epidemiological study. PLoS Neglected Tropical Diseases, 10(8), e0004874. https://doi.org/10.1371/journal.pntd.0004874 DOI: https://doi.org/10.1371/journal.pntd.0004874
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Copyright (c) 2026 Abdul Fahim Sarwary, Mohammad Dawood, Mahboobullah, Aminullah Noor, Ahmadullah Zahir

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