The Impact of Russian Knapweed's Extracts on Open Wound Healing Process in Rabbits

Ghulam Haidar Olfat; Emal Habibi; Mohammad Sangary; Amanullah Aziz; Said Ashraf Hashemi; Nick Mohammad Omari

doi:10.62810/jnsr.v3i1.177

Authors

Ghulam Haidar Olfat Kabul University, Department of Clinic, Faculty of Veterinary Science, Kabul, Afghanistan
Emal Habibi Kabul University, Department of Animal Production, Faculty of Veterinary Science, Kabul, Afghanistan
Mohammad Sangary Kabul University, Department of Paraclinic, Faculty of Veterinary Science, Kabul, Afghanistan
Amanullah Aziz Kabul University, Department of Clinic, Faculty of Veterinary Science, Kabul, Afghanistan
Said Ashraf Hashemi Kabul University, Department of Clinic, Faculty of Veterinary Science, Kabul, Afghanistan
Nick Mohammad Omari Kabul University, Department of Clinic, Faculty of Veterinary Science, Kabul, Afghanistan

DOI:

https://doi.org/10.62810/jnsr.v3i1.177

Keywords:

Russian Knapweed, Extract, Wound, Healing, Rabbits

Abstract

Skin is the body's outermost layer; therefore, it is more at risk and is injured by many factors such as surgery, illness, and burns. Numerous drugs are used to heal these wounds, each of which has several drawbacks, limitations, and side effects. So, it is important to prepare a substance that is accessible, cheap, without limitations and defects, with or without low side effects. Therefore, we decided to conduct a study to investigate the effects of extracts of Russian knapweed on open wound healing in rabbits. This research was conducted on 18 rabbits in the Faculty of Veterinary Sciences of Kabul University. Russian Knapweed root and stem extract were extracted using the decoction method. Then, a deep open wound was created in the animal's skin by a scalpel blade, and extracts were applied. The rabbits were randomly divided into the three (control, root, stem) groups. Results obtained from this research show that the vital signs of rabbits during the research were typical also on the four^th day; the root and stem groups had the highest healing rate, respectively. There is a significant difference compared to the control group, P < 0.05. On days 7^th, 10^th, and 13^th, the stem group had the highest healing rate, but the difference between this group and the control and root groups was insignificant P˃0.05. Generally, the results of this study show that the Russian Knapweed root and stem extract obtained by the decoction method did not have a good effect on wound healing. However, on the fourth day of wound evaluation, more than 50% of wounds in root and stem groups were healed.

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